IGF-1 LR3 1mg

SKU: PEP0008

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Description

IGF-1 LR3 stands as an 83 amino acid residue variant of native IGF-1, recognized for its role in promoting hyperplasia and cellular proliferation. This analogue is crafted by extending the original IGF-1 polypeptide with a 13 amino acid b-terminus and substituting Arg for Glu at position 3, thus earning the moniker Long Arg3. These alterations augment the biological activity of IGF-1 while enhancing its structural stability and prolonging its presence in the body.

Animal research showcases the capacity of IGF-1 LR3 to bind directly to natural IGF receptors, spurring the formation of new tissues while impeding programmed cell death (apoptosis) in existing ones. Particularly within muscle cells, IGF-1 variants facilitate the recruitment of amino acids and the synthesis of new proteins, while mitigating the breakdown of intracellular proteins for energy. Instead, fat reserves serve as the primary energy source as IGF-1 species exert their biochemical influence.

Physical AppearanceFine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
CAS143045-27-6