The peptide AICAR is a protein kinase agonist, meaning that it increases the usage of nutrient stores in order for the production of energy. It is tan in color, and is available for purchase in powder form. However, its purchase availability is only for the expressed, exclusive use of scientific study and research on animal test subjects. The peptide is occasionally labeled under the names Acadesine or ZMP.
How AICAR Works
In essence, AICAR works by stimulating the glucose uptake and increasing the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue. Additionally, its reduction of reactive oxygen compounds within cells suppresses apoptosis; that is, the process of programmed cellular death that may occur in animal test subjects. In other words, it increases the type of fuel responsible for the maintenance and regulation of skeletal muscle tissue while prolonging the life of cells.
The functionality of AICAR was pinpointed during extensive research conducted by the Salk Institute in 2008, when it conducted a battery of studies on laboratory rats. According to this particular research, it was determined that the mice that were given AICAR exhibited a significant improvement concerning endurance-type exercise. While the mechanics of this particular improvement were not isolated and specified, it was theorized that it was due to AICAR’s facility for converting fast-twitch muscle fibers to slow-twitch muscle fibers. This conversion in turn allowed for a much higher rate of energy efficiency amongst the lab rats. Additionally, the scientific tests noted that the conversion also allowed for a more efficient fat burning process amongst the animal test subjects.
AICAR’s Role in Treating Ischemic Injuries
Other scientific study conducted on animal test subjects has also determined that the peptide enters cardiac cells in order to inhibit adenosine kinase and adenosine deaminase. This process enhances the rate of nucleotide re-synthesis elevates adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia.
Because of these properties, it is theorized that the peptide could be utilized for the treatment of and the safeguarding against various cardiac ischemic injuries, which can either be construed as asymptomatic or brought upon by angina pectoris, which itself is primarily caused by arteriosclerosis and broken down into three different categories:
- Stable angina – Chest discomfort that is brought about by a measure of activity. This condition is typically abated within several minutes of an activity being stopped.
- Unstable angina – Also known s crescendo angina, this form of acute coronary syndrome is marked by angina that changes or worsens over a certain period of time.
- Microvascular angina – Also known as Angina Syndrome X, this condition is characterized by angina-like chest pain, but is theorized to be the result of spasm in the miniscule blood vessels of the heart as well as the arms and legs.
It is theorized that AICAR’s functionality would inhibit the restriction of blood flow to the heart muscle, which is a main condition of an ischemic injury. This in turn would enable the peptide to lower the risk of heart failure in animal test subjects. Additionally, it would enable it to assist in treating an animal test subject in the aftermath of an ischemic injury, as the increase in blood flow would allow an animal test subjects’ heart to be stabilized.
If you determine that the mechanics of AICAR are beneficial for your scientific study on animal test subjects, you should make sure you are following a couple of key steps in order to maximize the accuracy of your test results. The first step you should take is to check the purity of the peptide, as working with a diluted peptide may result in slight variances of scientific data that may ultimately cause issues over time, especially if your research is spread over several years. Secondly, you should make sure that you double-check the quantity of AICAR you would be receiving, just to confirm that the amount you are receiving is sufficient for your animal test subject study. Additionally, you should ensure that you are receiving complete and accurate research materials to accompany your peptide’s purpose.
Finally, you should always bear in mind that AICAR is currently in the research phase, and any study on its functionality and effects on animal test subjects should be contained to the confines of a strictly controlled environment like a laboratory or a medical research facility.