Anastrozole is a peptide that acts as a aromatase inhibitor. It is typically presented as an off-white powder with a molecular weight of 293.4. It contains moderate aqueous solubility.
Mechanics of Anastrozole
Scientific study on animal test subjects has determined that Anastrozole binds reversibly to the aromatase enzyme via competitive inhibition. This means that it the binding of the inhibitor to the active site on the enzyme prohibits binding on the molecule in which the enzyme acts and vice versa. This process blocks the conversion of androgens to estrogens in peripheral tissues. This in turn blocks the production of estrogen; the naturally occurring endocrine secretion that is responsible for the menstrual and estrous reproductive cycles in animal test subjects.
Theoretical Benefits of Anastrozole
The primary scientific study of Anastrozole through animal test subjects is focused on how its ability to inhibit the secretion of estrogen can play a role in certain endocrine-related cancers, particularly breast cancer. This is due to the fact that studies show that the severity of breast cancer is increased by the presence of estrogen. This is because the estrogen causes hyperplasia; that is, a proliferation of cells. It also causes differentiation at estrogen receptor sites, meaning that it causes a less specialized cell to become a more specialized cell type. Because the peptide has exhibited an ability to block the synthesis of estrogen, it is theorized that it could play a role in slowing down the progress of breast cancer.
Additionally, scientific study on animal test subjects has derived other theoretical benefits in association with Anastrozole and its ability to inhibit the production of estrogen. These theoretical benefits include:
- Treatment of benign prostatic hyperplasia – Commonly referred to as prostate enlargement, this condition is marked when large nodules compress the urethral canal in male animal test subjects, causing partial or complete obstruction of the urethra, which in turn disrupts the normal flow of urine.
- Treatment of gynecomastia – This refers to the benign enlargement of breast tissue in male animal test subjects. This condition is caused by excessive estrogen actions and is frequently the result in an elevated ratio of estrogen to androgen.
- Treatment of hypogonadism – This refers to a diminished functional activity of the testes in male animal test subjects and the ovaries in female animal test subjects.
- Treatment of precocious puberty – This condition is marked by the presence of bodily maturation occurring at an unusually early age.
Potential Negative Side Effects of Anastrozole
Scientific study on animal test subjects has determined that there are several negative side effects that are associated with the use of Anastrozole.
The primary negative side effect in relation to Anastrozole’s usage concerns the weakening of bones. Scientific research based on animal test subjects have determined that the use of the peptide can deplete the sturdiness and durability of bones in female animal test subjects. This is because the peptide inhibits certain secretions that are responsible for skeletal tissue building and repair on a cellular level. This could lead to several ailments related to bone weakness, up to and including osteoporosis.
Other serious negative side effects have been determined through scientific research on animal test subjects. These serious negative side effects include:
- Sudden numbness or weakness on one side of the body.
- Swollen glands.
- Shortness of breath.
- Sudden severe headache.
- Issues concerning vision.
- Issues concerning balance.
- Upper stomach pain
- Darkened urine
- Discoloration of stool
- Loss of appetite
Additionally, a host of less serious negative side effects have been associated with Anastrozole through scientific study on animal test subjects. These less serious negative side effects include:
- Joint pain
- Stiffness of joints
- Extremity issues. These include numbness, weakness, and tingling
- Back pain
- Bone pain
- Mild nausea
It has also been theorized that Anastrozole’s impact on estrogen secretion could cause various negative side effects amongst animal test subjects that are pregnant.
For Scientific Use Only
Although scientific study has been conducted on animal test subjects to determine Anastrozole’s range of operational mechanics, theoretical benefits, and negative side effects, it should be noted that any and all findings linked to the peptide are still rooted in contemporary laboratory research. Because Anastrozole is currently in the research phase, any usage or study relating to the mechanics, operations, effects, benefits, and side effects of the peptide should solely be contained to the restrictions of a strictly controlled environment such as a laboratory or a medical research facility.