IGF-1 DES refers to a cleaved version of the common peptide insulin-like growth factor 1. This is a truncated version of the peptide which includes soamtomedin C. Studies have found that this peptide is around 10 times more potent and functional than standard IGF-1 in regards to stimulating the proliferation of cells that have been cultured as well as stimulating hypertrophy. IGF-1 DES is also found to be more potent because this version of the peptide has removed glutamate from amino acid position 3.
Natural insulin-like growth factor 1 may be referred to interchangeably as somatomedin C depending on the application. This is a protein which humans have encoded by an animal’s body using the IGF gene. This is also known naturally as the sulfation factor which causes effects, something that the scientific community has deemed nonsuppressible insulin-like activity.
Synthesis or Circulation
IGF-1 is naturally produced in an animal’s liver, though there are some alternative sources for this peptide, which is used as an endocrine hormone which will target tissues in the autocrine or paracrine system.
- The production of IGF-1 is stimulated by the presence of growth hormone which is retarded when the animal is lacking the appropriate nutrition for ideal functionality.
- Growth hormone sensitivity or a lack of receptors for growth hormone as well as a failure of the signaling pathway downstream from these pathways can cause the animal’s body to fail to produce an adequate amount of IGF. The production and administration of IGF-1 DES is largely designed to address the needs of animals that have these conditions with potential human application if research is successful.
- Around 98 percent of IGF-1 is designed to bind with one of 6 proteins. The most common of these is IGFBP-3 which accounts for around 80 percent of all IGF binding with in an animal’s system.
In rats it has been found that IGF-1 in the mRNA found within the liver can be positively associated with dietary casein as well as being negatively associated with a diet that is lacking in protein. More recent research has found that the expression of plants in a system can be used to create a biologically active recumbent human version of IGF-1, known as rhIGF-1 in transgenic grains of rice.
Mechanisms of Action
The primary actions of IGF-1 and synthetic versions, including IGF-1 DES, is to bind to specific receptors, specifically IGF1R which is present in a variety of cell types that helps to make up a variety of different types of tissue.
- Binding with IGF1R creates a tyrosine kinase which will help the body to initiate intracellular signaling. The natural version of IGF-1 is considered to be the most potent natural activators within the signaling pathway (AKT). This helps to signal proliferation as well as cell growth, and in certain cases cell death.
- IGF-1 is one of the primary mediators on the effects that growth hormone will have on an animal. Growth hormone is produced within the anterior pituitary gland which will then release this chemical into the blood stream and stimulate the liver to produce the necessary amount of IGF-1 that will stimulate most cells in the body to grow.
- If these pathways are not functioning properly, scientists are hoping to stimulate specific areas of the body as necessary using synthesized or hyper-potent versions of these chemicals such as IGF-1 DES to get the necessary results.
IGF-1 as well as other tyrosine kinase growth factor receptors are used through signal pathways. A key of the pathway is regulated using P13K to move through the downstream current through the body. Those that are deficient in these chemicals are considered to be recombinant and often categorized as having Laron syndrome. This is particularly common in beef cattle.
Synthesizing IGF-1 DES can be done with a variety of chemical processes. This will help the chemical take on the specific properties necessary for a given application within an animal. This peptide is both created by truncating a standard IGF molecule structure and by replacing some of the existing amino acids or eliminating them all together in order to create a more stable molecule which has a longer half-life and is capable of reaching other tissues within the body.
Given the specific nature of this peptide it is important to perform careful research when looking for laboratory supplies in order to get a peptide that will create the anticipated results.