MK-2866 is one of the more common chemical names for endobasarm. This chemical may also be referred to as ostarine or GTx-024. This is an investigational selective androgen receptor modulator, which is developed by GTX. This is currently being researched for its potential in managing conditions such as osteoporosis or muscle wasting in animals. Previously this chemical was produced and marketed through Merck and Company.
According to the most recent publications from GTX, readers are encouraged to note that ostarine or MK-2866 are commonly mistaken for a similar chemical structure known as andarine. The chemical structure for MK-2866 has not been disclosed publically, which makes it impossible for outside companies to produce this formula. The chemical composition is available through patent databases and is discussed in patent literature for the brand at minimum.
There are a variety of SARM chemotypes which include quinolinones, propionamides, quinolones and bicylic hydantions, but these are aryl propionamides of MK-2866. These represent some of the more advanced putative metrics which are under investigation for their potential uses. The specific difference here is that MK-2877 has cyano substitutions on phenyl rings which replace the acetamido moieties and nitro moieties.
Antioxidiative Activity in Rabbits
Consuming a cholesterol right diet has been found to increase the amount of lipid peroxidation which is considered to be one of the top indicators of atherosclerosis in animals.
- Trials in this research worked to determine the antioxidative effects that naringin, a citruis bioflavonoid which can act as a cholesterol lowering agent with potent effects, compared to lovastatin which is a commonly used drug to lower cholesterol in patients.
- These chemicals were administered to male rabbits which were fed a high cholesterol diet or a diet that contained high amounts of cholesterol that was supplemented with lovastatin or narigin. This diet plan was continued for a full 8 weeks in order to determine the hepatic lipid peroxide, plasma, plasma vitamins E and A as well as hydrogen peroxide levels. This was also used to note the hepatic antioxidant enzyme activity and how this impacted the expression of genes.
- The only group which showed any significance in the lower of hepatic lipid peroxide or plasma levels was that which was provided with applications of lovastatin when they were compared to the control group.
- Those that were offered supplementation with niringin saw a noticeable increase in the activity of catalase and hepatic SOD by 20 and 33 percent respectively. The lovastatin group, by comparison, only saw a catalase increase by 23 percent when compared to the control group.
- The groups saw no difference in GSH Px activity and the content of H2o2 in the hepatic mitochondria was found to be noticeably lower in groups that were provided applications of lovastatin. The group that was provided niringin and the control group saw minimal difference.
- There was no difference in the content of H2O2 in the liver of rabbits when comparing across these control groups.
The concentration of vitamin E in the plasma within the rabbits was seen to increase in the group that was provided with applications of niringin. When this result was compared to the activity of the antioxidant enzyme gene expression, the expression of SOD in the mRNA and the catalase as well as the GSH Px was up-regulated at a significant rate.
The response to these results indicates that the citrus bioflavoinoid niringin has a vital role in helping an animal’s body to regulate the antioxidative capacities. This is done by increasing catalase activity and that of SOD. This chemical can also up-regulate the expression of SOD in the genes of the anima. This also allows for the protection of vitamin E within the plasma. To contrast these results, lovastatin was shown to create an inhibitory effect in the rabbits, both in the hepatic lipid peroxidation and the plasma. This was done by increasing the hepatic catalase activity in those that were continuing on a high cholesterol diet throughout the experiment.
Before purchasing MK-2866 for research purposes it is essential that you determine how this product is shipped and maintained before it arrives at your facility. This will help you to determine whether or not the shelf life and preservation of this chemical can be counted on for these chemicals to be used in a research setting.
Most peptides are shipped frozen and must be reconstituted as used in order to maintain them for months at a time. Once a peptide has been reconstituted it must be used within a few days to ensure that the half-life of the product can be maintained. It is also vital to work to find an authentic provider for this chemical, as the chemical formula is only available to a select view. Taking the time to research the validity of a chemical before buying can help to ensure that all results associated with MK-2866 will be accurate.